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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1615939
Species: Mus musculus
CRRD Object: Gene
Symbol: Thbs1
Name: thrombospondin 1
Acc ID: CHEBI:66910
Term: axitinib
Definition: An indazole substituted at position 3 by a 2-(pyridin-2-yl)vinyl group and at position 6 by a 2-(N-methylaminocarboxy)phenylsulfanyl group. Used for the treatment of advanced renal cell carcinoma after failure of a first line systemic treatment.
Chemical ID: MESH:C503983
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:15884556480464CTDaxitinib inhibits the reaction [Cyclophosphamide results in increased expression of THBS1 protein]

PMID:18202011
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.