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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1311841
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Akr1c2
Name: aldo-keto reductase family 1, member C2
Acc ID: CHEBI:6710
Term: meclofenamic acid
Definition: An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,6-dichloro-3-methylphenyl group. A non-steroidal anti-inflammatory drug, it is used as the sodium salt for the treatment of dysmenorrhoea (painful periods), osteoarthritis and rheumatoid arthritis.
Chemical ID: MESH:D008469
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityISOCRRD:13539016480464CTDMeclofenamic Acid results in decreased activity of AKR1C2 protein

PMID:19010312, PMID:26362498, PMID:27163852
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.