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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1312683
Species: Homo sapiens
CRRD Object: Gene
Symbol: EZH2
Name: enhancer of zeste 2 polycomb repressive complex 2 subunit
Acc ID: CHEBI:6716
Term: medroxyprogesterone acetate
Definition: A steroid ester that has formula C24H34O4.
Chemical ID: MESH:D017258
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDMedroxyprogesterone Acetate results in decreased expression of EZH2 mRNA, Medroxyprogesterone Acetate results in decreased expression of EZH2 protein

PMID:21903722
multiple interactionsEXP 6480464CTD[8-Bromo Cyclic Adenosine Monophosphate co-treated with Medroxyprogesterone Acetate] results in decreased expression of EZH2 mRNA, [8-Bromo Cyclic Adenosine Monophosphate co-treated with Medroxyprogesterone Acetate] results in decreased expression of EZH2 protein, EZH2 mutant form inhibits the reaction [[8-Bromo Cyclic Adenosine Monophosphate co-treated with Medroxyprogesterone Acetate] results in increased expression of IGFBP1 mRNA], EZH2 mutant form inhibits the reaction [[8-Bromo Cyclic Adenosine Monophosphate co-treated with Medroxyprogesterone Acetate] results in increased expression of PRL mRNA]

PMID:21903722
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.