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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1311841
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Akr1c2
Name: aldo-keto reductase family 1, member C2
Acc ID: CHEBI:6717
Term: mefenamic acid
Definition: An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,3-dimethylphenyl group. Although classed as a non-steroidal anti-inflammatory drug, its anti-inflammatory properties are considered to be minor. It is used to relieve mild to moderate pain, including headaches, dental pain, osteoarthritis and rheumatoid arthritis.
Chemical ID: MESH:D008528
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityISOCRRD:13539016480464CTDMefenamic Acid analog results in decreased activity of AKR1C2 protein

PMID:19010312
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.