GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2522
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Drd4
Name: dopamine receptor D4
Acc ID: CHEBI:6809
Term: methamphetamine
Definition: A member of the class of amphetamines in which the amino group of (S)-amphetamine carries a methyl substituent.
Chemical ID: MESH:D008694
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects response to substanceISOCRRD:7361386480464CTDDRD4 gene polymorphism affects the susceptibility to Methamphetamine

PMID:19462300
increases response to substanceISOCRRD:7361386480464CTDDRD4 gene polymorphism results in increased susceptibility to Methamphetamine

PMID:15274053
multiple interactionsISOCRRD:104876480464CTD[NRA 0160 binds to and results in decreased activity of DRD4 protein] which results in decreased susceptibility to Methamphetamine

PMID:10579464
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.