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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 61312
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Timp2
Name: TIMP metallopeptidase inhibitor 2
Acc ID: CHEBI:6809
Term: methamphetamine
Definition: A member of the class of amphetamines in which the amino group of (S)-amphetamine carries a methyl substituent.
Chemical ID: MESH:D008694
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases response to substanceISORGD:621786480464CTDTIMP2 protein results in decreased susceptibility to Methamphetamine

PMID:18198472
increases activityISORGD:621786480464CTDMethamphetamine results in increased activity of TIMP2 protein

PMID:18198472
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.