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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620064
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Chd4
Name: chromodomain helicase DNA binding protein 4
Acc ID: CHEBI:6809
Term: methamphetamine
Definition: A member of the class of amphetamines in which the amino group of (S)-amphetamine carries a methyl substituent.
Chemical ID: MESH:D008694
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases methylationISORGD:13226856480464CTDMethamphetamine results in decreased methylation of CHD4 promoter

PMID:26307267
increases expressionISORGD:13226856480464CTDMethamphetamine results in increased expression of CHD4 mRNA

PMID:26307267
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.