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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1345543
Species: Homo sapiens
CRRD Object: Gene
Symbol: GRK1
Name: G protein-coupled receptor kinase 1
Acc ID: CHEBI:6897
Term: metipranolol
Definition: 3-(Propan-2-ylamino)propane-1,2-diol in which the hydrogen of the primary hydroxy group is substituted by a 4-acetoxy-2,3,5-trimethylphenoxy group. A non-cardioselective beta-blocker, it is used to lower intra-ocular pressure in the management of open-angle glaucoma.
Chemical ID: MESH:D014290
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:6197126480464CTDMetipranolol inhibits the reaction [Zinc results in decreased expression of GRK1 protein], Metipranolol inhibits the reaction [Zinc Sulfate results in decreased expression of GRK1 protein]

PMID:16799065
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.