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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620495
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Rsad2
Name: radical S-adenosyl methionine domain containing 2
Acc ID: CHEBI:71200
Term: tofacitinib
Definition: A pyrrolopyrimidine that is pyrrolo[2,3-d]pyrimidine substituted at position 4 by an N-methyl,N-(1-cyanoacetyl-4-methylpiperidin-3-yl)amino moiety. Used as its citrate salt to treat moderately to severely active rheumatoid arthritis.
Chemical ID: MESH:C479163
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:13453036480464CTDtofacitinib results in decreased expression of RSAD2 mRNA

PMID:25487280
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