GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3771
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Stat1
Name: signal transducer and activator of transcription 1
Acc ID: CHEBI:71415
Term: nitrofurantoin
Definition: An imidazolidine-2,4-dione that is hydantoin substituted at position 1 by a [(5-nitro-2-furyl)methylene]amino group. An antibiotic that damages bacterial DNA.
Chemical ID: MESH:D009582
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISOCRRD:7321846480464CTDNitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein]

Rotenone promotes the reaction [Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein]]

PMID:15748169
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.