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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1552153
Species: Mus musculus
CRRD Object: Gene
Symbol: Agtrap
Name: angiotensin II, type I receptor-associated protein
Acc ID: CHEBI:72544
Term: flavonoids
Definition: Any organic molecular entity whose stucture is based on derivatives of a phenyl-substituted 1-phenylpropane possessing a C15 or C16 skeleton, or such a structure which is condensed with a C6-C3 lignan precursors. The term is a 'superclass' comprising all members of the classes of flavonoid, isoflavonoid, neoflavonoid, chalcones, dihydrochalcones, aurones, pterocarpan, coumestans, rotenoid, flavonolignan, homoflavonoid and flavonoid oligomers. Originally restricted to natural products, the term is also applied to synthetic compounds related to them.
Chemical ID: MESH:D005419
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:13501516480464CTDFlavonoids inhibits the reaction [AGT protein results in increased expression of AGTRAP protein], Flavonoids inhibits the reaction [BCL2 mutant form promotes the reaction [AGT protein results in increased expression of AGTRAP protein]]

PMID:23994555
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.