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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2059
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Adrb1
Name: adrenoceptor beta 1
Acc ID: CHEBI:73289
Term: ICI 118551
Definition: An indane substituted at position 7 by a methyl group and at position 4 by a 3-(isopropylamino)-2-hydroxybutoxy group (the 2R,3S-diastereomer).
Chemical ID: MESH:C026777
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[Dobutamine co-treated with ICI 118551] results in decreased expression of ADRB1 mRNA, [Dobutamine co-treated with ICI 118551] results in decreased expression of ADRB1 protein, ICI 118551 inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]

PMID:19719783, PMID:9260993
multiple interactionsISORGD:7312896480464CTD[ICI 118551 binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP, ICI 118551 binds to and results in decreased activity of ADRB1 protein, ICI 118551 inhibits the reaction [cyanopindolol binds to ADRB1 protein]

PMID:14730417
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.