GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3704
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Slc2a1
Name: solute carrier family 2 member 1
Acc ID: CHEBI:73918
Term: 3-O-methyl-D-glucose
Definition: A D-aldohexose that is D-glucose in which the hydrogen of the hydroxy group at position 3 has been substituted by a methyl group. It is a non-metabolisable glucose analogue that is not phosphorylated by hexokinase and is used as a marker to assess glucose transport by evaluating its uptake within various cells and organ systems.
Chemical ID: MESH:D019325
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases transportISOCRRD:7372726480464CTDSLC2A1 protein mutant form results in decreased transport of 3-O-Methylglucose

PMID:11603379
increases uptakeISOCRRD:7372726480464CTDSLC2A1 protein results in increased uptake of 3-O-Methylglucose

PMID:10590023
multiple interactionsISOCRRD:7372726480464CTDPentobarbital inhibits the reaction [SLC2A1 protein results in increased uptake of 3-O-Methylglucose]

Pentobarbital promotes the reaction [SLC2A1 gene polymorphism results in decreased uptake of 3-O-Methylglucose]

Phenobarbital inhibits the reaction [SLC2A1 protein results in increased uptake of 3-O-Methylglucose]

Phenobarbital promotes the reaction [SLC2A1 gene polymorphism results in decreased uptake of 3-O-Methylglucose]

PMID:10590023
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.