GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3947
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Utrn
Name: utrophin
Acc ID: CHEBI:7443
Term: nabumetone
Definition: A methyl ketone that is 2-butanone in which one of the methyl hydrogens at position 4 is replaced by a 6-methoxy-2-naphthyl group. A prodrug that is converted to the active metabolite, 6-methoxy-2-naphthylacetic acid, following oral administration. It is shown to have a slightly lower risk of gastrointestinal side effects than most other non-steroidal anti-inflammatory drugs.
Chemical ID: MESH:C035605
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISOCRRD:7313416480464CTDnabumetone results in increased expression of UTRN mRNA

nabumetone results in increased expression of UTRN protein

PMID:22028826
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.