GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620047
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Il2
Name: interleukin 2
Acc ID: CHEBI:7476
Term: naproxen
Definition: A methoxynaphthalene that is 2-methoxynaphthalene substituted by a carboxy ethyl group at position 6. Naproxen is a non-steroidal anti-inflammatory drug commonly used for the reduction of pain, fever, inflammation and stiffness caused by conditions such as osteoarthritis, kidney stones, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, menstrual cramps, tendinitis, bursitis, and for the treatment of primary dysmenorrhea. It works by inhibiting both the COX-1 and COX-2 enzymes.
Chemical ID: MESH:D009288
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL2 protein]

Naproxen inhibits the reaction [Capsaicin results in increased expression of IL2 protein]

PMID:22150557
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.