GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 631435
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Orc1
Name: origin recognition complex, subunit 1
Acc ID: CHEBI:75170
Term: zaragozic acid A
Definition: A polyketide isolated from fungi that is a potent inhibitor of fungal and mammalian squalene synthase.
Chemical ID: MESH:C075117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDsqualestatin 1 results in decreased expression of ORC1 mRNA

PMID:27225895
decreases expressionISOCRRD:13321826480464CTDsqualestatin 1 results in decreased expression of ORC1 mRNA

PMID:27225895
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.