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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1562456
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Skp2
Name: S-phase kinase associated protein 2
Acc ID: CHEBI:75408
Term: sulindac sulfide
Definition: An aryl sulfide that is a metabolite of sulindac. A non-steroidal anti-inflammatory drug, which also has anticancer activity.
Chemical ID: MESH:C025462
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:16070866480464CTDsulindac sulfide results in decreased expression of SKP2 mRNA

PMID:16184548
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.