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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 733705
Species: Homo sapiens
CRRD Object: Gene
Symbol: CTNNB1
Name: catenin beta 1
Acc ID: CHEBI:7553
Term: Niclosamide
Definition: null
Chemical ID: MESH:D009534
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityEXP 6480464CTDNiclosamide results in decreased activity of CTNNB1 protein

PMID:25174399
decreases expressionEXP 6480464CTDNiclosamide analog results in decreased expression of CTNNB1 protein, Niclosamide results in decreased expression of CTNNB1 protein

PMID:21531761, PMID:24552774, PMID:24736023, PMID:27492973, PMID:28284560
increases expressionEXP 6480464CTDNiclosamide results in increased expression of CTNNB1 mRNA

PMID:22576131
increases ubiquitinationEXP 6480464CTDNiclosamide results in increased ubiquitination of CTNNB1 protein

PMID:27492973
multiple interactionsEXP 6480464CTDImatinib Mesylate promotes the reaction [Niclosamide results in decreased expression of CTNNB1 protein], Niclosamide inhibits the reaction [CTNNB1 protein binds to CTNNBIP1 protein], Niclosamide inhibits the reaction [Lithium Chloride affects the localization of CTNNB1 protein], Niclosamide inhibits the reaction [TNF protein affects the localization of CTNNB1 protein], Niclosamide inhibits the reaction [WNT3A protein affects the localization of CTNNB1 protein], Niclosamide inhibits the reaction [WNT3A protein results in increased stability of CTNNB1 protein], Niclosamide promotes the reaction [Imatinib Mesylate results in decreased expression of CTNNB1 protein]

PMID:19772353, PMID:24534281, PMID:27492973
decreases expressionISORGD:15504666480464CTDNiclosamide results in decreased expression of CTNNB1 mRNA

PMID:27226553
multiple interactionsISORGD:704876480464CTDNiclosamide inhibits the reaction [Epinephrine results in increased phosphorylation of CTNNB1 protein], Niclosamide inhibits the reaction [GCG protein results in increased phosphorylation of CTNNB1 protein]

PMID:26964897
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.