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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2018
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Acly
Name: ATP citrate lyase
Acc ID: CHEBI:75998
Term: trametinib
Definition: A pyridopyrimidine that is used (as its dimethyl sulfoxide addition compound) for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E or V600K mutations, and who have not received prior BRAF inhibitor treatment.
Chemical ID: MESH:C560077
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:100656480464CTDtrametinib affects the reaction [[BRAF protein affects the susceptibility to Vemurafenib] which affects the expression of ACLY mRNA]

PMID:29950559
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