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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 730881
Species: Homo sapiens
CRRD Object: Gene
Symbol: HRAS
Name: HRas proto-oncogene, GTPase
Acc ID: CHEBI:76290
Term: PhIP
Definition: An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.
Chemical ID: MESH:C049584
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects response to substanceEXP 6480464CTDHRAS protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine

PMID:22307971
increases expressionEXP 6480464CTD2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine results in increased expression of HRAS mRNA, 2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine results in increased expression of HRAS protein

PMID:22307971
increases mutagenesisEXP 6480464CTD2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine results in increased mutagenesis of HRAS gene

PMID:15132766
multiple interactionsEXP 6480464CTDHRAS protein affects the reaction [2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine results in increased abundance of Reactive Oxygen Species], HRAS protein affects the reaction [2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine results in increased expression of NOX1 protein], HRAS protein affects the reaction [2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine results in increased phosphorylation of MAPK1 protein], HRAS protein affects the reaction [2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine results in increased phosphorylation of MAPK3 protein]

PMID:22307971
increases mutagenesisISORGD:28276480464CTD2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine results in increased mutagenesis of HRAS gene

PMID:11165753, PMID:9433479
multiple interactionsISORGD:28276480464CTD2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine results in increased mutagenesis of and results in increased activity of HRAS, [2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine results in increased abundance of 2-amino-1-methyl-6-phenolimidazo(4, 5-b)pyridine-DNA adduct] which results in increased mutagenesis of HRAS gene, [2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine results in increased mutagenesis of HRAS gene] which results in increased activity of HRAS protein, Dietary Fats affects the reaction [2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine results in increased mutagenesis of HRAS gene]

PMID:12507937, PMID:8039140, PMID:9433479
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.