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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620575
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Apaf1
Name: apoptotic peptidase activating factor 1
Acc ID: CHEBI:76451
Term: alloxan
Definition: A member of the class of pyrimidones, the structure of which is that of perhydropyrimidine substituted at C-2, -4, -5 and -6 by oxo groups.
Chemical ID: MESH:D000496
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDAlloxan results in decreased expression of APAF1 protein

PMID:21982801
increases expressionEXP 6480464CTDAlloxan results in increased expression of APAF1 protein

PMID:23092809
multiple interactionsEXP 6480464CTDTaurine inhibits the reaction [Alloxan results in increased expression of APAF1 protein]

PMID:23092809
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.