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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1310333
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Itga3
Name: integrin subunit alpha 3
Acc ID: CHEBI:77149
Term: notoginsenoside R1
Definition: A ginsenoside found in Panax notoginseng that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy groups at positions 6 and 20 have been converted to the corresponding beta-D-xylopyranosyl-(1->2)-beta-D-glucopyranoside and beta-D-glucopyranoside respectively, and in which a double bond has been introduced at the 24-25 position.
Chemical ID: MESH:C072936
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:13211786480464CTDnotoginsenoside R1 inhibits the reaction [Glucose results in decreased expression of ITGA3 mRNA], notoginsenoside R1 inhibits the reaction [Glucose results in decreased expression of ITGA3 protein], notoginsenoside R1 inhibits the reaction [Streptozocin results in decreased expression of ITGA3 mRNA], notoginsenoside R1 inhibits the reaction [Streptozocin results in decreased expression of ITGA3 protein]

PMID:25503068
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.