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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 61312
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Timp2
Name: TIMP metallopeptidase inhibitor 2
Acc ID: CHEBI:7719
Term: ochratoxin A
Definition: A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.
Chemical ID: MESH:C025589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases acetylationISORGD:7339066480464CTDochratoxin A results in increased acetylation of TIMP2 promoter

PMID:29098329
increases expressionISORGD:7339066480464CTDochratoxin A results in increased expression of TIMP2 mRNA

PMID:29098329
multiple interactionsISORGD:621786480464CTD[NFE2L2 protein affects the susceptibility to ochratoxin A] which results in increased expression of TIMP2 mRNA

PMID:28710020
multiple interactionsISORGD:7339066480464CTD[ochratoxin A results in increased acetylation of TIMP2 promoter] which results in increased expression of TIMP2 mRNA

PMID:29098329
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.