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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1307932
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cldn4
Name: claudin 4
Acc ID: CHEBI:78492
Term: diallyl trisulfide
Definition: An organic trisulfide that is trisulfane in which both of the hydrogens are replaced by allyl groups. A component of the essential oil of garlic and a major component of the traditional Chinese medicine allitridium, it exhibits antifungal, antitumour and antioxidant activity
Chemical ID: MESH:C042577
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:13174136480464CTDdiallyl trisulfide results in decreased expression of CLDN4 mRNA, diallyl trisulfide results in decreased expression of CLDN4 protein

PMID:24084732
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.