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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621121
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cdk6
Name: cyclin-dependent kinase 6
Acc ID: CHEBI:78543
Term: ponatinib
Definition: A benzamide obtained by the formal condensation of the carboxy group of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzoic acid with the anilino group of 4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)aniline.
Chemical ID: MESH:C545373
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:7354006480464CTDponatinib results in decreased expression of CDK6 protein

PMID:25053825
multiple interactionsISORGD:7354006480464CTD(+)-JQ1 compound promotes the reaction [ponatinib results in decreased expression of CDK6 protein], ponatinib promotes the reaction [(+)-JQ1 compound results in decreased expression of CDK6 protein]

PMID:25053825
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.