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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 61312
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Timp2
Name: TIMP metallopeptidase inhibitor 2
Acc ID: CHEBI:78741
Term: oxidopamine
Definition: A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).
Chemical ID: MESH:D016627
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:7339066480464CTDOxidopamine results in decreased expression of TIMP2 mRNA, Oxidopamine results in decreased expression of TIMP2 protein

PMID:19883732
decreases response to substanceISORGD:7339066480464CTDTIMP2 protein results in decreased susceptibility to Oxidopamine

PMID:19883732
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.