GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2387
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cp
Name: ceruloplasmin
Acc ID: CHEBI:78782
Term: pyrrolidine dithiocarbamate
Definition: A member of the class of dithiocarbamic acids that is the N-dithiocarboxy derivative of pyrrolidine.
Chemical ID: MESH:C020972
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISOCRRD:7367826480464CTDpyrrolidine dithiocarbamic acid results in increased expression of CP mRNA

pyrrolidine dithiocarbamic acid results in increased expression of CP protein

PMID:17032174
increases secretionISOCRRD:7367826480464CTDpyrrolidine dithiocarbamic acid results in increased secretion of CP protein

PMID:17032174
multiple interactionsISOCRRD:7367826480464CTDbathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid promotes the reaction [[JUN protein binds to FOS protein] which results in increased expression of and results in increased activity of CP protein]]

bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid results in increased expression of CP protein]

Copper promotes the reaction [pyrrolidine dithiocarbamic acid promotes the reaction [[JUN protein binds to FOS protein] which results in increased expression of and results in increased activity of CP protein]]

Copper promotes the reaction [pyrrolidine dithiocarbamic acid results in increased expression of CP protein]

PMID:17032174
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.