GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 70069
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cxcl2
Name: C-X-C motif chemokine ligand 2
Acc ID: CHEBI:7939
Term: parthenolide
Definition: A sesquiterpene lactone and active principle of Feverfew (Tanacetum parthenium).
Chemical ID: MESH:C002669
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISOCRRD:7331186480464CTDparthenolide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CXCL2 mRNA]

parthenolide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CXCL2 protein]

PMID:21507677
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.