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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621032
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nr0b2
Name: nuclear receptor subfamily 0, group B, member 2
Acc ID: CHEBI:79997
Term: GW 4064
Definition: A stilbenoid that has formula C28H22Cl3NO4.
Chemical ID: MESH:C412815
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDGW 4064 results in increased expression of NR0B2 mRNA

PMID:14623915, PMID:15644430, PMID:15980055
increases expressionISORGD:7328736480464CTDGW 4064 results in increased expression of NR0B2 mRNA

PMID:16269825, PMID:22178739, PMID:22414727, PMID:25550158, PMID:30611723
increases expressionISORGD:7328746480464CTDGW 4064 results in increased expression of NR0B2 mRNA

PMID:19072826, PMID:22918042, PMID:23178280, PMID:26241054, PMID:27609522, PMID:30245210
multiple interactionsISORGD:7328736480464CTD[GW 4064 binds to and results in increased activity of NR1H4 protein] which results in increased expression of NR0B2 mRNA, [GW 4064 co-treated with Oleic Acid] results in increased expression of NR0B2 mRNA, epigallocatechin gallate inhibits the reaction [GW 4064 results in increased expression of NR0B2 mRNA]

PMID:22178739, PMID:22540009, PMID:30611723
multiple interactionsISORGD:7328746480464CTD[GW 4064 binds to and results in increased activity of NR1H4 protein] which results in increased expression of NR0B2 mRNA, ATP7B protein affects the reaction [GW 4064 results in increased expression of NR0B2 mRNA], GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of NR0B2 mRNA], GW 4064 inhibits the reaction [ATP7B gene mutant form results in decreased expression of NR0B2 mRNA], GW 4064 promotes the reaction [NR1H4 protein binds to NR0B2 gene], NR0B2 protein promotes the reaction [GW 4064 results in decreased expression of AHCYL2 mRNA], NR0B2 protein promotes the reaction [GW 4064 results in decreased expression of GNMT mRNA], NR0B2 protein promotes the reaction [GW 4064 results in decreased expression of MTFMT mRNA], NR0B2 protein promotes the reaction [GW 4064 results in decreased expression of MTHFR mRNA], NR0B2 protein promotes the reaction [GW 4064 results in decreased expression of PEMT mRNA], NR1H4 gene mutant form inhibits the reaction [GW 4064 results in increased expression of NR0B2 mRNA], NR1H4 mutant form inhibits the reaction [GW 4064 results in increased expression of NR0B2 mRNA], Stigmasterol promotes the reaction [GW 4064 results in increased expression of NR0B2 mRNA]

PMID:19072826, PMID:20091679, PMID:21480330, PMID:22540009, PMID:22918042, PMID:26241054, PMID:28223344, PMID:29416063, PMID:30245210
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.