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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1309970
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Gsta4
Name: glutathione S-transferase alpha 4
Acc ID: CHEBI:8069
Term: phenobarbital
Definition: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Chemical ID: MESH:D010634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDPhenobarbital results in increased expression of GSTA4 mRNA, Phenobarbital results in increased expression of GSTA4 protein

PMID:19162173, PMID:9794803
multiple interactionsEXP 6480464CTD[Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of GSTA4 protein

PMID:20935162
decreases expressionISORGD:13206016480464CTDPhenobarbital results in decreased expression of GSTA4 mRNA

PMID:19084549
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.