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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620575
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Apaf1
Name: apoptotic peptidase activating factor 1
Acc ID: CHEBI:80774
Term: tauroursodeoxycholic acid
Definition: A bile acid taurine conjugate derived from ursoodeoxycholic acid.
Chemical ID: MESH:C031655
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDtauroursodeoxycholic acid affects the expression of APAF1 mRNA, tauroursodeoxycholic acid affects the expression of APAF1 protein

PMID:15885361
decreases expressionEXP 6480464CTDtauroursodeoxycholic acid results in decreased expression of APAF1 mRNA

PMID:15885361
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.