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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3194
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nppb
Name: natriuretic peptide B
Acc ID: CHEBI:8093
Term: phenylephrine
Definition: A member of the class of the class of phenylethanolamines that is (1R)-2-(methylamino)-1-phenylethan-1-ol carrying an additional hydroxy substituent at position 3 on the phenyl ring.
Chemical ID: MESH:D010656
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDPhenylephrine results in increased expression of NPPB mRNA

Phenylephrine results in increased expression of NPPB protein

PMID:11754973, PMID:11799083, PMID:11854500, PMID:12435817, PMID:16556869, PMID:18701451, PMID:18790048, PMID:20067472, PMID:23939492, PMID:25358972, PMID:27094368, PMID:27094369, PMID:28759639, PMID:28822817
increases secretionEXP 6480464CTDPhenylephrine results in increased secretion of NPPB protein

PMID:10642269, PMID:11754973, PMID:12435817, PMID:20067472
multiple interactionsEXP 6480464CTD(+)-JQ1 compound inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]

[GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]

[pirinixic acid binds to PPARA protein] inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]

[SIRT6 protein co-treated with EP300 protein] affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]

CEP-11004 inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]

CEP-11004 inhibits the reaction [Phenylephrine results in increased secretion of NPPB protein]

EP300 protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]

GRK2 protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]

HS 142-1 promotes the reaction [Phenylephrine results in increased secretion of NPPB protein]

JUN gene mutant form inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]

MOV10L1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]

MYOCD protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]

PDE5A protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]

PRKCZ protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]

Sildenafil Citrate inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]

SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]

PMID:10642269, PMID:11799083, PMID:11854500, PMID:16556869, PMID:18701451, PMID:18790048, PMID:20067472, PMID:23939492, PMID:27094368, PMID:27094369, PMID:28759639
increases expressionISOCRRD:110046480464CTDPhenylephrine results in increased expression of NPPB mRNA

PMID:11804996, PMID:16603706, PMID:18502941
multiple interactionsISOCRRD:110046480464CTDANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]

HEY2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]

PMID:16603706, PMID:18502941
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.