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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 733581
Species: Homo sapiens
CRRD Object: Gene
Symbol: COX17
Name: cytochrome c oxidase copper chaperone COX17
Acc ID: CHEBI:8093
Term: phenylephrine
Definition: A member of the class of the class of phenylethanolamines that is (1R)-2-(methylamino)-1-phenylethan-1-ol carrying an additional hydroxy substituent at position 3 on the phenyl ring.
Chemical ID: MESH:D010656
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:6205486480464CTDPhenylephrine results in decreased expression of COX17 protein

PMID:23818984, PMID:25107896
multiple interactionsISORGD:6205486480464CTDCopper Sulfate inhibits the reaction [Phenylephrine results in decreased expression of COX17 protein], periodate-oxidized adenosine inhibits the reaction [Phenylephrine results in decreased expression of COX17 protein], VEGFA protein inhibits the reaction [Phenylephrine results in decreased expression of COX17 protein]

PMID:23818984, PMID:25107896
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.