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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2482
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cyp7a1
Name: cytochrome P450 family 7 subfamily A member 1
Acc ID: CHEBI:8107
Term: phenytoin
Definition: A imidazolidine-2,4-dione that consists of hydantoin bearing two phenyl substituents at position 5.
Chemical ID: MESH:D010672
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:104586480464CTD[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP7A1 mRNA

PMID:21224054
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.