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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 737494
Species: Homo sapiens
CRRD Object: Gene
Symbol: SYP
Name: synaptophysin
Acc ID: CHEBI:82436
Term: decabromodiphenyl ether
Definition: A polybromodiphenyl ether that is diphenyl ether in which all of the hydrogens have been replaced by bromines.
Chemical ID: MESH:C010902
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:38026480464CTDdecabromobiphenyl ether results in decreased expression of SYP mRNA, decabromobiphenyl ether results in decreased expression of SYP protein

PMID:28104350
increases expressionISORGD:113736480464CTDdecabromobiphenyl ether metabolite results in increased expression of SYP protein, decabromobiphenyl ether results in increased expression of SYP protein

PMID:19380496, PMID:25194327
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.