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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1308692
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nfatc3
Name: nuclear factor of activated T-cells 3
Acc ID: CHEBI:8249
Term: piroxicam
Definition: A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic acid 1,1-dioxide with the exocyclic nitrogen of 2-aminopyridine. A non-steroidal anti-inflammatory drug of the oxicam class, it is used to relieve pain and works by preventing the production of endogenous prostaglandins involved in the mediation of pain, stiffness, tenderness and swelling.
Chemical ID: MESH:D010894
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISOCRRD:13186136480464CTD[Piroxicam co-treated with Cisplatin] results in increased expression of NFATC3 mRNA

PMID:21858171
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.