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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1316819
Species: Homo sapiens
CRRD Object: Gene
Symbol: FECH
Name: ferrochelatase
Acc ID: CHEBI:82664
Term: iron(0)
Definition: An elemental iron in which the atom has an oxidation state of zero.
Chemical ID: MESH:D007501
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[pyridoxal isonicotinoyl hydrazone results in decreased abundance of Iron] which results in decreased expression of FECH protein

PMID:30517741
multiple interactionsISORGD:13168206480464CTD[Aminolevulinic Acid results in decreased activity of FECH protein] which results in increased abundance of Iron, [Griseofulvin results in decreased activity of FECH protein] which results in decreased uptake of Iron, [Porphobilinogen results in decreased activity of FECH protein] which results in increased abundance of Iron, heme arginate inhibits the reaction [[Griseofulvin results in decreased activity of FECH protein] which results in decreased uptake of Iron]

PMID:15078340
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.