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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1587390
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Prkg1
Name: protein kinase cGMP-dependent 1
Acc ID: CHEBI:85102
Term: KT 5823
Definition: An organic heterooctacyclic compound that is 1H,1'H-2,2'-biindole in which the nitrogens have undergone formal oxidative coupling to positions 2 and 5 of methyl (3R)-3-methoxy-2-methyltetrahydrofuran-3-carboxylate (the 2S,3R,5R product), and in which the 3 and 3' positions of the biindole moiety have also undergone formal oxidative coupling to positions 3 and 4 of 1-methyl-1,5-dihydro-2H-pyrrol-2-one.
Chemical ID: MESH:C073601
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prkg1multiple interactionsISORGD:13224426480464CTDKT 5823 inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3', 5'-GMP promotes the reaction [PRKG1 protein binds to and results in increased phosphorylation of ARHGEF17 protein]], KT 5823 inhibits the reaction [[8-((4-chlorophenyl)thio)cyclic-3', 5'-GMP co-treated with PRKG1 protein] results in increased activity of RHOA protein]

PMID:23195829
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.