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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 70500
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:85102
Term: KT 5823
Definition: An organic heterooctacyclic compound that is 1H,1'H-2,2'-biindole in which the nitrogens have undergone formal oxidative coupling to positions 2 and 5 of methyl (3R)-3-methoxy-2-methyltetrahydrofuran-3-carboxylate (the 2S,3R,5R product), and in which the 3 and 3' positions of the biindole moiety have also undergone formal oxidative coupling to positions 3 and 4 of 1-methyl-1,5-dihydro-2H-pyrrol-2-one.
Chemical ID: MESH:C073601
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1multiple interactionsEXP 6480464CTDKT 5823 promotes the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]

PMID:16389725
Mapk1multiple interactionsISORGD:7325026480464CTDKT 5823 affects the reaction [heat stable toxin (E coli) results in decreased phosphorylation of MAPK1 protein]

PMID:17828804
Mapk1multiple interactionsISORGD:7325036480464CTDKT 5823 inhibits the reaction [2-(3, 4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5, 1-f)(1, 2, 4)triazin-4 (3H)-one inhibits the reaction [Corticosterone results in increased phosphorylation of MAPK1 protein]]

PMID:22850435
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.