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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1305490
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Runx1t1
Name: RUNX1 partner transcriptional co-repressor 1
Acc ID: CHEBI:85990
Term: panobinostat
Definition: A hydroxamic acid obtained by formal condensation of the carboxy group of (2E)-3-[4-({[2-(2-methylindol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enoic acid with the amino group of hydroxylamine. A histone deacetylase inhibitor used (as its lactate salt) in combination with bortezomib and dexamethasone for the treatment of multiple myeloma.
Chemical ID: MESH:C496932
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:13502616480464CTDpanobinostat results in increased expression of RUNX1T1 mRNA

PMID:26272509
multiple interactionsISORGD:13502616480464CTD[NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RUNX1T1 mRNA

PMID:27188386
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.