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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1605705
Species: Homo sapiens
CRRD Object: Gene
Symbol: GREB1
Name: growth regulating estrogen receptor binding 1
Acc ID: CHEBI:8772
Term: raloxifene
Definition: A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogens at positions 2, 3, and 6 have been replaced by p-hydroxyphenyl, p-[2-(piperidin-1-yl)ethoxy]benzoyl, and hydroxy groups, respectively.
Chemical ID: MESH:D020849
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDRaloxifene Hydrochloride results in decreased expression of GREB1 mRNA

PMID:21185374
multiple interactionsEXP 6480464CTDRaloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of GREB1 mRNA]

PMID:21185374
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.