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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 730858
Species: Homo sapiens
CRRD Object: Gene
Symbol: IL2
Name: interleukin 2
Acc ID: CHEBI:88217
Term: N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine
Definition: An N-substituted diamine that is ethylenediamine in which the four amino hydrogens are replaced by 2-pyridylmethyl groups.
Chemical ID: MESH:C044387
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7333156480464CTDN, N, N', N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [IL2 protein results in increased expression of FOS mRNA], N, N, N', N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK1 protein], N, N, N', N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK3 protein], N, N, N', N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [IL2 protein results in increased phosphorylation of STAT5A protein], N, N, N', N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [IL2 protein results in increased phosphorylation of STAT5B protein]

PMID:20201035
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.