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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621121
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cdk6
Name: cyclin-dependent kinase 6
Acc ID: CHEBI:88339
Term: BMS-754807
Definition: A pyrrolotriazine that is pyrrolo[2,1-f][1,2,4]triazine which is substituted at position 2 by the pyrrolidine nitrogen of (2S)-N-(6-fluoropyridin-3-yl)-2-methylprolinamide, and at position 4 by a (5-cyclopropyl-1H-pyrazol-3-yl)amino group. It is a potent, reversible inhibitor of the insulin-like growth factor 1 receptor/insulin receptor family kinases.
Chemical ID: MESH:C545990
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISOCRRD:7354006480464CTD[[CDK4 mutant form co-treated with CDK6 mutant form] results in increased susceptibility to BMS 754807] which results in decreased phosphorylation of RPS6KB1 protein

[CDK4 mutant form co-treated with CDK6 mutant form] results in increased susceptibility to BMS 754807

PMID:24986516
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.