GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621121
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cdk6
Name: cyclin-dependent kinase 6
Acc ID: CHEBI:90217
Term: quizartinib
Definition: A member of the class of phenylureas that is urea in which one of the amino groups has been substituted by a 5-tert-butyl-1,2-oxazol-3-yl group while the other has been substituted by a phenyl group substituted at the para- position by an imidazo[2,1-b][1,3]benzothiazol-2-yl group that, in turn, is substituted at position 7 by a 2-(morpholin-4-yl)ethoxy group.
Chemical ID: MESH:C544967
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISOCRRD:7354006480464CTDquizartinib results in decreased expression of CDK6 protein

PMID:25053825
multiple interactionsISOCRRD:7354006480464CTD(+)-JQ1 compound promotes the reaction [quizartinib results in decreased expression of CDK6 protein]

quizartinib promotes the reaction [(+)-JQ1 compound results in decreased expression of CDK6 protein]

PMID:25053825
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.