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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 70981
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Bco1
Name: beta-carotene oxygenase 1
Acc ID: CHEBI:90706
Term: Ro 41-5253
Definition: A thiochromane that is 3,4-dihydro-2H-1-benzothiopyran S,S-dioxide in which the hydrogens at position 4 are both replaced by methyl groups, the hydrogens at position 7 is replaced by a heptyloxy group, while the hydrogen at position 6 is replaced by a 1-phenylprop-1-en-2-yl group, the phenyl group of which is substituted at the para position by a carboxy group. It is a selective antagonist for retinoic acid receptor alpha.
Chemical ID: MESH:C084904
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:13465526480464CTDRo 41-5253 results in increased expression of BCO1 mRNA, Ro 41-5253 results in increased expression of BCO1 protein

PMID:16186334
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