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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1348516
Species: Homo sapiens
CRRD Object: Gene
Symbol: GPR55
Name: G protein-coupled receptor 55
Acc ID: CHEBI:90724
Term: AM-251
Definition: A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.
Chemical ID: MESH:C103505
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityEXP 6480464CTDAM 251 results in increased activity of GPR55 protein

PMID:27423937
multiple interactionsEXP 6480464CTD4'-methoxy-1-naphthylfenoterol inhibits the reaction [AM 251 results in increased activity of GPR55 protein], 4-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H, 4H, 5H, 6H-pyrrolo(3, 4-c)pyrazol-5-yl)benzoic acid inhibits the reaction [AM 251 results in increased activity of GPR55 protein]

PMID:27423937
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.