GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620707
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Tff1
Name: trefoil factor 1
Acc ID: CHEBI:91462
Term: SU6656
Definition: A member of the class of oxindoles that is 3-methyleneoxindole in which the hydrogeh at position 5 has been replaced by a dimethylaminosulfonyl group and in which one of the hydrogens of the methylene group has been replaced by a 4,5,6,7-tetrahydro-indol-2-yl group. It is a specific inhibitor of Src family kinase.
Chemical ID: MESH:C416927
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISOCRRD:13446716480464CTDSU 6656 inhibits the reaction [afimoxifene results in increased expression of TFF1 mRNA]

SU 6656 inhibits the reaction [Estradiol results in increased expression of TFF1 mRNA]

PMID:15528270
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.