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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621295
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Mvk
Name: mevalonate kinase
Acc ID: CHEBI:9150
Term: simvastatin
Definition: A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
Chemical ID: MESH:D019821
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDSimvastatin results in increased expression of MVK mRNA

PMID:25055962
multiple interactionsISORGD:7320316480464CTD[MVK gene mutant form results in increased activity of HMGCR protein] which results in increased susceptibility to Simvastatin, MVK gene mutant form promotes the reaction [Simvastatin results in decreased activity of HMGCR protein], MVK gene mutant form promotes the reaction [Simvastatin results in decreased farnesylation of and affects the localization of HRAS protein], MVK gene mutant form promotes the reaction [Simvastatin results in decreased geranoylation of and affects the localization of RHOA protein]

PMID:12477733
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.