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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 14043101
Species: Sus scrofa
CRRD Object: Gene
Symbol: INS
Name: insulin
Acc ID: CHEBI:9168
Term: sirolimus
Definition: A macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.
Chemical ID: MESH:D020123
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
INSdecreases expressionEXP 6480464CTDSirolimus results in decreased expression of INS mRNA, Sirolimus results in decreased expression of INS protein

PMID:20622751
INSmultiple interactionsEXP 6480464CTDSirolimus inhibits the reaction [Glucose results in increased secretion of INS protein]

PMID:20622751
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