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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 619838
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Pabpc1
Name: poly(A) binding protein, cytoplasmic 1
Acc ID: CHEBI:9168
Term: sirolimus
Definition: A macrolide isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.
Chemical ID: MESH:D020123
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:13498486480464CTDSirolimus results in decreased expression of PABPC1 protein

PMID:25940091
multiple interactionsISORGD:13498486480464CTDSirolimus inhibits the reaction [EIF4G1 protein binds to PABPC1 mRNA], Sirolimus promotes the reaction [LARP1 protein binds to PABPC1 mRNA]

PMID:25940091
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.